| dc.contributor.author | Kooffreh, M.E. |
| dc.contributor.author | Anumudu, C.I. |
| dc.contributor.author | Kumar, P.L. |
| dc.date.accessioned | 2019-12-04T11:03:30Z |
| dc.date.available | 2019-12-04T11:03:30Z |
| dc.date.issued | 2014 |
| dc.identifier.citation | Kooffreh, M. E., Anumudu, C. I. & Kumar, P. L. (2014). Insertion/deletion polymorphism of the angiotensin-converting enzyme gene and the risk of hypertension among residents of two cities, South-South Nigeria. Advanced biomedical research, 3. |
| dc.identifier.issn | 2277-9175 |
| dc.identifier.uri | https://hdl.handle.net/20.500.12478/1110 |
| dc.description.abstract | Background: Hypertension is a public health challenge due to its high prevalence, and is a major risk factor for cardiovascular diseases. This study was designed to determine the frequency of the I/D polymorphism of the angiotensin-converting enzyme gene and its association with hypertension in a sample population of Calabar and Uyo, South-South Nigeria. Materials and Methods: A population-based case control design consisting of total of 1224 participants, 612 each of patients and controls, were randomly recruited from hypertension clinics and the general population. The I/D polymorphism was investigated using polymerase chain reaction. Multiple regression and odds ratio (OR) was applied to test whether the ID genotypes were predictors of hypertension. Results: The I/D genotype frequencies were 73(12%), 262(43%) and 277(45%); 74(12%), 303(50%) and 235(38%) for the II, ID, DD genotype in patient and control groups, respectively. A higher frequency of the ID genotype was observed in controls of which 208(61%) were females. By multiple regression analysis, age was a predictor for SBP in patients, r = 0.596, and DBP in controls, r = 0.555. Gender, Body mass index, I/D genotypes were not significant predictors for hypertension but the I/D polymorpism was associated with an increased risk for hypertension with an OR of 1.15 95%CI (0.924-1.456). Conclusion: The I/D polymorphism of the angiotensin-converting enzyme gene was a risk factor for hypertension in the sample population of Calabar and Uyo. This research will form baseline information for subsequent molecular studies in this population. Key Words: Angiotensin-converting enzyme gene, frequency |
| dc.language.iso | en |
| dc.subject | Angiotensin |
| dc.subject | Hypertension |
| dc.subject | Genotypes |
| dc.subject | Polymorphism |
| dc.title | Insertion/deletion polymorphism of the angiotensinconverting enzyme gene and the risk of hypertension among residents of two cities, SouthSouth Nigeria |
| dc.type | Journal Article |
| dc.description.version | Peer Review |
| cg.contributor.affiliation | University of Calabar |
| cg.contributor.affiliation | University of Ibadan |
| cg.contributor.affiliation | International Institute of Tropical Agriculture |
| cg.coverage.region | Africa |
| cg.coverage.region | West Africa |
| cg.coverage.country | Nigeria |
| cg.authorship.types | CGIAR and developing country institute |
| cg.journal | Advanced Biomedical Research |
| cg.howpublished | Formally Published |
| cg.accessibilitystatus | Open Access |
| local.dspaceid | 78108 |
| cg.identifier.doi | https://dx.doi.org/10.4103/2277-9175.133184 |
