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Associations between common variants in iron-related genes with haematological traits in populations of African ancestry

dc.contributor.authorGichohi-Wainaina, Wanjiku N.
dc.contributor.authorTanaka, Toshiko
dc.contributor.authorTowers, G. Wayne
dc.contributor.authorVerhoef, Hans
dc.contributor.authorVeenemans, Jacobien
dc.contributor.authorTalsma, Elise F.
dc.contributor.authorHarryvan, Jan
dc.contributor.authorBoekschoten, Mark V.
dc.contributor.authorFeskens, Edith J.
dc.contributor.authorMelse-Boonstra, Alida
dc.date.accessioned2019-12-04T11:03:38Z
dc.date.available2019-12-04T11:03:38Z
dc.date.issued2016-06-22
dc.identifier.citationGichohi-Wainaina, Wanjiku N.; Tanaka, Toshiko; Towers, G. Wayne; Verhoef, Hans; Veenemans, Jacobien; Talsma, Elise; Harryvan, Jan; Boekschoten, Mark V.; Feskens, Edith J.; Melse-Boonstra, Alida. 2016. Associations between common variants in iron-related genes with haematological traits in populations of African ancestry . PLoS ONE 11(6): e0157996.
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/20.500.12478/1172
dc.description.abstractBackground Large genome-wide association (GWA) studies of European ancestry individuals have identified multiple genetic variants influencing iron status. Studies on the generalizability of these associations to African ancestry populations have been limited. These studies are important given interethnic differences in iron status and the disproportionate burden of iron deficiency among African ancestry populations. Methods We tested the associations of 20 previously identified iron status-associated single nucleotide polymorphisms (SNPs) in 628 Kenyans, 609 Tanzanians, 608 South Africans and 228 African Americans. In each study, we examined the associations present between 20 SNPs with ferritin and haemoglobin, adjusting for age, sex and CRP levels. Results In the meta analysis including all 4 African ancestry cohorts, we replicated previously reported associations with lowered haemoglobin concentrations for rs2413450 (β = -0.19, P = 0.02) and rs4820268 (β = -0.16, P = 0.04) in TMPRSS6. An association with increased ferritin concentrations was also confirmed for rs1867504 in TF (β = 1.04, P = <0.0001) in the meta analysis including the African cohorts only. Conclusions In all meta analyses, we only replicated 4 of the 20 single nucleotide polymorphisms reported to be associated with iron status in large GWA studies of European ancestry individuals. While there is now evidence for the associations of a number of genetic variants with iron status in both European and African ancestry populations, the considerable lack of concordance highlights the importance of continued ancestry-specific studies to elucidate the genetic underpinnings of iron status in ethnically diverse populations.
dc.format.extent11(6): e0157996
dc.language.isoen
dc.subjectFerritin
dc.subjectGenotypes
dc.subjectDeficiencies
dc.subjectIron
dc.subjectInflammation
dc.subjectPopulation Genetics
dc.subjectGenomics
dc.subjectFerritín
dc.subjectGenotipos
dc.subjectHierro
dc.subjectInflamación
dc.subjectGenética De Poblaciones
dc.subjectGenómica
dc.titleAssociations between common variants in iron-related genes with haematological traits in populations of African ancestry
dc.typeJournal Article
dc.description.versionPeer Review
cg.contributor.crpAgriculture for Nutrition and Health
cg.coverage.regionAfrica
cg.coverage.regionEast Africa
cg.isijournalISI Journal
cg.journalPLOS ONE
cg.howpublishedFormally Published
cg.accessibilitystatusOpen Access
local.dspaceid78270
cg.identifier.doihttps://dx.doi.org/10.1371/journal.pone.0157996


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