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dc.contributor.authorChen, J.
dc.contributor.authorShrestha, R.
dc.contributor.authorDing, J.
dc.contributor.authorZheng, H.
dc.contributor.authorMu, C.
dc.contributor.authorWu, J.
dc.contributor.authorMahuku, George S.
dc.date.accessioned2019-12-04T11:04:11Z
dc.date.available2019-12-04T11:04:11Z
dc.date.issued2016
dc.identifier.citationChen, J., Shrestha, R., Ding, J., Zheng, H., Mu, C., Wu, J. & Mahuku, G. (2016). Genome-wide association study and QTL mapping reveal genomic loci associated with Fusarium ear rot resistance in tropical maize germplasm. G3: Genes| Genomes| Genetics, g3-116.
dc.identifier.issn2160-1836
dc.identifier.urihttps://hdl.handle.net/20.500.12478/1361
dc.descriptionPublished online: 14 October 2016; Open Access Journal
dc.description.abstractFusarium ear rot (FER) incited by Fusarium verticillioides is a major disease of maize that reduces grain quality globally. Host resistance is the most suitable strategy for managing the disease. We report the results of genome-wide association study (GWAS) to detect alleles associated with increased resistance to FER in a set of 818 tropical maize inbred lines evaluated in three environments. Association tests performed using 43,424 single-nucleotide polymorphic (SNPs) markers identified 45 SNPs and 15 haplotypes that were significantly associated with FER resistance. Each associated SNP locus had relatively small additive effects on disease resistance and accounted for 1% to 4% of trait variation. These SNPs and haplotypes were located within or adjacent to 38 candidate genes, 21 of which were candidate genes associated with plant tolerance to stresses, including disease resistance. Linkage mapping in four bi-parental populations to validate GWAS results identified 15 quantitative trait loci (QTL) associated with F. verticillioides resistance. Integration of GWAS and QTL to the maize physical map showed eight co-located loci on Chromosomes 2, 3, 4, 5, 9 and 10. QTL on chromosomes 2 and 9 are new. These results reveal that FER resistance is a complex trait that is conditioned by multiple genes with minor effects. The value of selection on identified markers for improving FER resistance is limited; rather, selection to combine small effect resistance alleles combined with genomic selection for polygenic background for both the target and general adaptation traits might be fruitful for increasing FER resistance in maize.
dc.description.sponsorshipRegional Fund for Agricultural Technology
dc.description.sponsorshipBill & Melinda Gates Foundation
dc.format.extent1-48
dc.language.isoen
dc.subjectMaize
dc.subjectDisease Resistance
dc.subjectQuantitative Trait Loci
dc.subjectFusarium
dc.subjectHost Resistance To Diseases
dc.titleGenome-wide association study and QTL mapping reveal genomic loci associated with Fusarium ear rot resistance in tropical maize germplasm
dc.typeJournal Article
dc.description.versionPeer Review
cg.contributor.crpMaize
cg.contributor.affiliationHenan Agricultural University
cg.contributor.affiliationInternational Maize and Wheat Improvement Center
cg.contributor.affiliationInternational Institute of Tropical Agriculture
cg.contributor.affiliationShanghai Academy of Agricultural Sciences
cg.contributor.affiliationShandong Academy of Agricultural Sciences
cg.coverage.regionAfrica
cg.coverage.regionEast Africa
cg.coverage.regionNorth America
cg.coverage.regionSouth America
cg.coverage.countryColombia
cg.coverage.countryKenya
cg.coverage.countryMexico
cg.coverage.countryZimbabwe
cg.isijournalISI Journal
cg.authorship.typesCGIAR and developing country institute
cg.iitasubjectDisease Control
cg.iitasubjectMaize
cg.journalG3-Genes Genomes Genetics
cg.howpublishedFormally Published
cg.accessibilitystatusOpen Access
local.dspaceid79459
cg.targetaudienceScientists
cg.identifier.doihttps://dx.doi.org/10.1534/g3.116.034561


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