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Genome-Wide Association Mapping of Correlated Traits in Cassava: Dry Matter and Total Carotenoid Content

dc.contributor.authorRabbi, Ismail Y
dc.contributor.authorUdoh, L.I.
dc.contributor.authorWolfe, M.
dc.contributor.authorParkes, E.Y.
dc.contributor.authorGedil, M.A.
dc.contributor.authorDixon, A.
dc.contributor.authorRamu, P.
dc.contributor.authorJannink, Jean-Luc
dc.contributor.authorKulakow, P.A.
dc.date.accessioned2019-12-04T11:09:07Z
dc.date.available2019-12-04T11:09:07Z
dc.date.issued2017-11
dc.identifier.citationRabbi, I.Y., Udoh, L.I., Wolfe, M., Parkes, E.Y., Gedil, M.A., Dixon, A., ... & Kulakow, P. (2017). Genome-wide association mapping of correlated traits in cassava: dry matter and total carotenoid content. The Plant Genome, 10(3), 1-14.
dc.identifier.issn1940-3372
dc.identifier.urihttps://hdl.handle.net/20.500.12478/1980
dc.descriptionArticle purchased; Published online: 3 August 2017
dc.description.abstractCassava (Manihot esculenta (L.) Crantz) is a starchy root crop cultivated in the tropics for fresh consumption and commercial processing. Dry matter content and micronutrient density, particularly of provitamin A, traits that are negatively correlated, are among the primary selection objectives in cassava breeding. This study aimed at identifying genetic markers associated with these traits and uncovering the potential underlying cause of their negative correlation - whether linkage and/or pleiotropy. A genome-wide association mapping using 672 clones genotyped at 72,279 SNP loci was carried out. Root yellowness was used indirectly to assess variation in carotenoid content. Two major loci for root yellowness was identified on chromosome 1 at positions 24.1 and 30.5 Mbp. A single locus for dry matter content that co-located with the 24.1 Mbp peak for carotenoid content was identified. Haplotypes at these loci explained a large proportion of the phenotypic variability. Evidence of mega-base-scale linkage disequilibrium around the major loci of the two traits and detection of the major dry matter locus in independent analysis for the white- and yellow-root subpopulations suggests that physical linkage rather that pleiotropy is more likely to be the cause of the negative correlation between the target traits. Moreover, candidate genes for carotenoid (phytoene synthase) and starch biosynthesis (UDP-glucose pyrophosphorylase and sucrose synthase) occurred in the vicinity of the identified locus at 24.1 Mbp. These findings elucidate on the genetic architecture of carotenoids and dry matter in cassava and provides an opportunity to accelerate genetic improvement of these traits.
dc.description.sponsorshipBill & Melinda Gates Foundation
dc.description.sponsorshipDepartment for International Development, United Kingdom
dc.format.extent1-14
dc.language.isoen
dc.subjectCassava
dc.subjectProduction
dc.subjectProcessing
dc.subjectFarmers
dc.subjectCarotenoid
dc.subjectGenome
dc.subjectDry Matter Content
dc.subjectTraits
dc.subjectGenetic Markers
dc.subjectMapping
dc.subjectBreeding
dc.subjectGermplasm
dc.titleGenome-Wide Association Mapping of Correlated Traits in Cassava: Dry Matter and Total Carotenoid Content
dc.typeJournal Article
dc.description.versionPeer Review
cg.contributor.crpRoots, Tubers and Bananas
cg.contributor.affiliationInternational Institute of Tropical Agriculture
cg.contributor.affiliationCornell University
cg.contributor.affiliationCornell University
cg.coverage.regionAfrica
cg.coverage.regionWest Africa
cg.coverage.countryNigeria
cg.isijournalISI Journal
cg.authorship.typesCGIAR and advanced research institute
cg.iitasubjectCassava
cg.iitasubjectGenetic Improvement
cg.iitasubjectPlant Genetic Resources
cg.journalThe Plant Genome
cg.howpublishedFormally Published
cg.accessibilitystatusOpen Access
local.dspaceid85536
cg.targetaudienceScientists
cg.identifier.doihttp://dx.doi.org/10.3835/plantgenome2016.09.0094


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