| dc.contributor.author | Gong, Y. |
| dc.contributor.author | Hounsa, A. |
| dc.contributor.author | Egal, S. |
| dc.contributor.author | Turner, P.C. |
| dc.contributor.author | Sutcliffe, A.E. |
| dc.contributor.author | Hall, A.J. |
| dc.contributor.author | Cardwell, K. |
| dc.contributor.author | Wild, C.P. |
| dc.date.accessioned | 2019-12-04T11:22:15Z |
| dc.date.available | 2019-12-04T11:22:15Z |
| dc.date.issued | 2004-09 |
| dc.identifier.citation | Gong, Y., Hounsa, A., Egal, S., Turner, P.C., Sutcliffe, A.E., Hall, A.J., ... & Wild, C.P. (2004). Postweaning exposure to aflatoxin results in impaired child growth: a longitudinal study in Benin, West Africa. Environmental Health Perspectives, 112(13), 1334-1338. |
| dc.identifier.issn | 0091-6765 |
| dc.identifier.uri | https://hdl.handle.net/20.500.12478/3974 |
| dc.description.abstract | Aflatoxins are dietary contaminants that are hepatocarcinogenic and immunotoxic and cause growth retardation in animals, but there is little evidence concerning the latter two parameters in exposed human populations. Aflatoxin exposure of West African children is known to be high, so we conducted a longitudinal study over an 8-month period in Benin to assess the effects of exposure on growth. Two hundred children 16–37 months of age were recruited from four villages, two with high and two with low aflatoxin exposure (50 children per village). Serum aflatoxin–albumin (AF-alb) adducts, anthropometric parameters, information on food consumption, and various demographic data were measured at recruitment (February) and at two subsequent time points (June and October). Plasma levels of vitamin A and zinc were also measured. AF-alb adducts increased markedly between February and October in three of the four villages, with the largest increases in the villages with higher exposures. Children who were fully weaned at recruitment had higher AF-alb than did those still partially breast-fed (p < 0.0001); the major weaning food was a maize-based porridge. There was no association between AF-alb and micronutrient levels, suggesting that aflatoxin exposure was not accompanied by a general nutritional deficiency. There was, however, a strong negative correlation (p < 0.0001) between AF-alb and height increase over the 8-month follow-up after adjustment for age, sex, height at recruitment, socioeconomic status, village, and weaning status; the highest quartile of AF-alb was associated with a mean 1.7 cm reduction in growth over 8 months compared with the lowest quartile. This study emphasizes the association between aflatoxin and stunting, although the underlying mechanisms remain unclear. Aflatoxin exposure during the weaning period may be critical in terms of adverse health effects in West African children, and intervention measures to reduce exposure merit investigation. |
| dc.language.iso | en |
| dc.subject | Aflatoxins |
| dc.subject | Dietary |
| dc.subject | Weaning |
| dc.title | Postweaning exposure to aflatoxin results in impaired child growth: a longitudinal study in Benin, West Africa |
| dc.type | Journal Article |
| dc.description.version | Peer Review |
| cg.contributor.affiliation | University of Leeds |
| cg.contributor.affiliation | International Institute of Tropical Agriculture |
| cg.contributor.affiliation | London School of Hygiene and Tropical Medicine |
| cg.coverage.region | Africa |
| cg.coverage.region | West Africa |
| cg.coverage.country | Benin |
| cg.isijournal | ISI Journal |
| cg.authorship.types | CGIAR and advanced research institute |
| cg.iitasubject | Aflatoxin |
| cg.accessibilitystatus | Limited Access |
| local.dspaceid | 99260 |
| cg.identifier.doi | https://doi.org/10.1289%2Fehp.6954 |
