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Aspergillus flavus resident in Kenya: high genetic diversity in an ancient population primarily shaped by clonal reproduction and mutation-driven evolution

dc.contributor.authorIslam, M.S.
dc.contributor.authorCallicott, K.A.
dc.contributor.authorMutegi, C.
dc.contributor.authorBandyopadhyay, Ranajit
dc.contributor.authorCotty, P.J.
dc.date.accessioned2019-12-04T11:26:30Z
dc.date.available2019-12-04T11:26:30Z
dc.date.issued2018-10
dc.identifier.citationIslam, M.S., Callicott, K.A., Mutegi, C., Bandyopadhyay, R. & Cotty, P.J. (2018). Aspergillus flavus resident in Kenya: high genetic diversity in an ancient population primarily shaped by clonal reproduction and mutation-driven evolution. Fungal Ecology, 35, 20-33.
dc.identifier.issn1754-5048
dc.identifier.urihttps://hdl.handle.net/20.500.12478/4630
dc.descriptionOpen Access Article
dc.description.abstractAspergillus flavus has long been considered to be an asexual species. Although a sexual stage was recently reported for this species from in vitro studies, the amount of recombination ongoing in natural populations and the genetic distance across which meiosis occurs is largely unknown. In the current study, genetic diversity, reproduction and evolution of natural A. flavus populations endemic to Kenya were examined. A total of 2744 isolates recovered from 629 maize-field soils across southern Kenya in two consecutive seasons were characterized at 17 SSR loci, revealing high genetic diversity (9-72 alleles/locus and 2140 haplotypes). Clonal reproduction and persistence of clonal lineages predominated, with many identical haplotypes occurring in multiple soil samples and both seasons. Genetic analyses predicted three distinct lineages with linkage disequilibrium and evolutionary relationships among haplotypes within each lineage suggesting mutation-driven evolution followed by clonal reproduction. Low genetic differentiation among adjacent communities reflected frequent short distance dispersal.
dc.description.sponsorshipBill & Melinda Gates Foundation
dc.description.sponsorshipUnited States Agency for International Development
dc.format.extent20-33
dc.language.isoen
dc.rightsCC-BY-4.0
dc.subjectAspergillus Flavus
dc.subjectGenetic Variation
dc.subjectReproduction
dc.subjectEvolution
dc.subjectAflatoxins
dc.subjectSimple Sequence Repeat
dc.titleAspergillus flavus resident in Kenya: high genetic diversity in an ancient population primarily shaped by clonal reproduction and mutation-driven evolution
dc.typeJournal Article
dc.description.versionPeer Review
cg.contributor.crpAgriculture for Nutrition and Health
cg.contributor.crpMaize
cg.contributor.crpGrain Legumes
cg.contributor.affiliationUniversity of Arizona
cg.contributor.affiliationInternational Institute of Tropical Agriculture
cg.coverage.regionAfrica
cg.coverage.regionEast Africa
cg.coverage.countryKenya
cg.creator.identifierCharity Mutegi: 0000-0002-3188-0480
cg.creator.identifierRanajit Bandyopadhyay: 0000-0003-2422-4298
cg.researchthemePLANT PRODUCTION & HEALTH
cg.isijournalISI Journal
cg.authorship.typesCGIAR and advanced research institute
cg.iitasubjectAflatoxin
cg.iitasubjectGenetic Improvement
cg.iitasubjectPlant Health
cg.iitasubjectPlant Production
cg.journalFungal Ecology
cg.howpublishedFormally Published
cg.accessibilitystatusOpen Access
local.dspaceid101309
cg.targetaudienceScientists
cg.identifier.doihttps://dx.doi.org/10.1016/j.funeco.2018.05.012


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