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    Antiviral and cytotoxic activity of different plant parts of banana (Musa spp.)

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    Journal Article (663.1Kb)
    Date
    2020-05-15
    Author
    Panda, S.K.
    Castro, A.H.F.
    Jouneghani, R.S.
    Leyssen, P.,
    Neyts, J.
    Swennen, R.
    Luyten, W.
    Type
    Journal Article
    Review Status
    Peer Review
    Target Audience
    Scientists
    Metadata
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    Abstract/Description
    Chikungunya and yellow fever virus cause vector-borne viral diseases in humans. There is currently no specific antiviral drug for either of these diseases. Banana plants are used in traditional medicine for treating viral diseases such as measles and chickenpox. Therefore, we tested selected banana cultivars for their antiviral but also cytotoxic properties. Different parts such as leaf, pseudostem and corm, collected separately and extracted with four different solvents (hexane, acetone, ethanol, and water), were tested for in vitro antiviral activity against Chikungunya virus (CHIKV), enterovirus 71 (EV71), and yellow fever virus (YFV). Extracts prepared with acetone and ethanol from leaf parts of several cultivars exhibited strong (EC50 around 10 μg/mL) anti-CHIKV activity. Interestingly, none of the banana plant extracts (concentration 1–100 µg/mL) were active against EV71. Activity against YFV was restricted to two cultivars: Namwa Khom–Pseudostem–Ethanol (5.9 ± 5.4), Namwa Khom–Corm–Ethanol (0.79 ± 0.1) and Fougamou–Corm–Acetone (2.5 ± 1.5). In most cases, the cytotoxic activity of the extracts was generally 5- to 10-fold lower than the antiviral activity, suggesting a reasonable therapeutic window.
    https://dx.doi.org/10.3390/v12050549
    Multi standard citation
    Permanent link to this item
    https://hdl.handle.net/20.500.12478/7639
    IITA Authors ORCID
    Rony Swennenhttps://orcid.org/0000-0002-5258-9043
    Digital Object Identifier (DOI)
    https://dx.doi.org/10.3390/v12050549
    Research Themes
    Biotech and Plant Breeding
    IITA Subjects
    Agronomy; Banana; Disease Control; Plant Breeding; Plant Diseases; Plant Production
    Agrovoc Terms
    Bananas; Chikungunya Virus; Cytotoxicity; Enterovirus; Plant Diseases
    Regions
    ACP; Europe
    Countries
    Belgium
    Hubs
    Eastern Africa Hub
    Journals
    Viruses
    Collections
    • Journal and Journal Articles4835
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