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Biofortified yellow cassava and vitamin A status of Kenyan children: a randomized controlled trial

dc.contributor.authorTalsma, E.F.
dc.contributor.authorBrouwer, Inge D.
dc.contributor.authorVerhoef, H.
dc.contributor.authorMbera, G.N.
dc.contributor.authorNwangi, A.M.
dc.contributor.authorDemir, Ayse Y.
dc.contributor.authorMaziya-Dixon, B.
dc.contributor.authorBoy, Erick
dc.contributor.authorZimmermann, Michael B.
dc.contributor.authorMelse-Boonstra, Alida
dc.date.accessioned2019-12-04T10:57:34Z
dc.date.available2019-12-04T10:57:34Z
dc.date.issued2016-01
dc.identifier.citationTalsma, E.F., Brouwer, I.D., Verhoef, H., Mbera, G.N., Mwangi, A.M., Demir, A.Y., ... & Melse-Boonstra, A. (2016). Biofortified yellow cassava and vitamin A status of Kenyan children: a randomized controlled trial. The American journal of clinical nutrition, 103(1), 258-267.
dc.identifier.issn0002-9165
dc.identifier.urihttps://hdl.handle.net/20.500.12478/780
dc.descriptionFirst published December 16, 2015
dc.description.abstractBackground: Whereas conventional white cassava roots are devoid of provitamin A, biofortified yellow varieties are naturally rich in b-carotene, the primary provitamin A carotenoid. Objective: We assessed the effect of consuming yellow cassava on serum retinol concentration in Kenyan schoolchildren with marginal vitamin A status. Design: We randomly allocated 342 children aged 5–13 y to receive daily, 6 d/wk, for 18.5 wk 1) white cassava and placebo supplement (control group), 2) provitamin A–rich cassava (mean content: 1460 mg b-carotene/d) and placebo supplement (yellow cassava group), and 3) white cassava and b-carotene supplement (1053 mg/d; b-carotene supplement group). The primary outcome was serum retinol concentration; prespecified secondary outcomes were hemoglobin concentration and serum concentrations of b-carotene, retinol-binding protein, and prealbumin. Groups were compared by using ANCOVA, adjusting for inflammation, baseline serum concentrations of retinol and b-carotene, and stratified design. Results: The baseline prevalence of serum retinol concentration, 0.7 mmol/L and inflammation was 27% and 24%, respectively. For children in the control, yellow cassava, and b-carotene supplement groups, the mean daily intake of cassava was 378, 371, and 378 g, respectively, and the total daily supply of provitamin A and vitamin A from diet and supplements was equivalent to 22, 220, and 175 mg retinol, respectively. Both yellow cassava and b-carotene supplementation increased serum retinol concentration by 0.04 mmol/L (95% CI: 0.00, 0.07 mmol/L); correspondingly, serum b-carotene concentration increased by 524% (448%, 608%) and 166% (134%, 202%). We found no effect on hemoglobin concentration or serum concentrations of retinol-binding protein and prealbumin. Conclusions: In our study population, consumption of yellow cassava led to modest gains in serum retinol concentration and a large increase in b-carotene concentration. It can be an efficacious, new approach to improve vitamin A status. This study was registered with clinicaltrials.gov as NCT01614483.
dc.format.extent258-267
dc.language.isoen
dc.subjectNutrition
dc.subjectConsumption
dc.subjectVitamin A
dc.subjectCassava
dc.titleBiofortified yellow cassava and vitamin A status of Kenyan children: a randomized controlled trial
dc.typeJournal Article
dc.description.versionPeer Review
cg.contributor.crpRoots, Tubers and Bananas
cg.contributor.affiliationWageningen University and Research Centre
cg.contributor.affiliationLondon School of Hygiene and Tropical Medicine
cg.contributor.affiliationUniversity of Nairobi
cg.contributor.affiliationMeander Medical Centre
cg.contributor.affiliationInternational Institute of Tropical Agriculture
cg.contributor.affiliationHarvestPlus
cg.contributor.affiliationSwiss Federal Institute of Technology
cg.coverage.regionAfrica
cg.coverage.regionEast Africa
cg.coverage.countryKenya
cg.isijournalISI Journal
cg.authorship.typesCGIAR and developing country institute
cg.iitasubjectCassava
cg.journalAmerican Journal of Clinical Nutrition
cg.howpublishedFormally Published
cg.accessibilitystatusOpen Access
local.dspaceid74854
cg.targetaudienceScientists
cg.identifier.doihttps://dx.doi.org/10.3945/ajcn.114.100164


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