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Association mapping of candidate genes associated with iron and zinc content in rice (Oryza sativa L.) grains

dc.contributor.authorBukomarhe, C.B.
dc.contributor.authorKimwemwe, P.K.
dc.contributor.authorGithiri, S.M.
dc.contributor.authorMamati, E.G.
dc.contributor.authorKimani, W.
dc.contributor.authorMutai, C.
dc.contributor.authorNganga, F.
dc.contributor.authorDontsop-Nguezet, P.
dc.contributor.authorMignouna, J.
dc.contributor.authorCivava, R.M.
dc.contributor.authorFofana, M.
dc.date.accessioned2023-11-02T12:02:41Z
dc.date.available2023-11-02T12:02:41Z
dc.date.issued2023-09
dc.identifier.citationBukomarhe, C.B., Kimwemwe, P.K., Githiri, S.M., Mamati, E.G., Kimani, W., Mutai, C., ... & Fofana, M. (2023). Association mapping of candidate genes associated with iron and zinc content in rice (Oryza sativa L.) grains. Genes, 14(9): 1815, 1-15.
dc.identifier.issn2073-4425
dc.identifier.urihttps://hdl.handle.net/20.500.12478/8331
dc.description.abstractMicronutrient deficiencies, particularly of iron (Fe) and zinc (Zn), in the diet contribute to health issues and hidden hunger. Enhancing the Fe and Zn content in globally staple food crops like rice is necessary to address food malnutrition. A Genome-Wide Association Study (GWAS) was conducted using 85 diverse rice accessions from the Democratic Republic of Congo (DRC) to identify genomic regions associated with grain Fe and Zn content. The Fe content ranged from 0.95 to 8.68 mg/100 g on a dry weight basis (dwb) while Zn content ranged from 0.87 to 3.8 mg/100 g (dwb). Using MLM and FarmCPU models, we found 10 significant SNPs out of which one SNP on chromosome 11 was associated with the variation in Fe content and one SNP on chromosome 4 was associated with the Zn content, and both were commonly detected by the two models. Candidate genes belonging to transcription regulator activities, including the bZIP family genes and MYB family genes, as well as transporter activities involved in Fe and Zn homeostasis were identified in the vicinity of the SNP markers and selected. The identified SNP markers hold promise for marker-assisted selection in rice breeding programs aimed at enhancing Fe and Zn content in rice. This study provides valuable insights into the genetic factors controlling Fe and Zn uptake and their transport and accumulation in rice, offering opportunities for developing biofortified rice varieties to combat malnutrition among rice consumers.
dc.description.sponsorshipWorld Bank
dc.format.extent1-15
dc.language.isoen
dc.subjectRice
dc.subjectZinc
dc.subjectOryza Sativa
dc.subjectPlant Genetics
dc.subjectSingle Nucleotide Polymorphism
dc.subjectGenes
dc.titleAssociation mapping of candidate genes associated with iron and zinc content in rice (Oryza sativa L.) grains
dc.typeJournal Article
cg.contributor.affiliationJomo Kenyatta University of Agriculture and Technology
cg.contributor.affiliationInternational Institute of Tropical Agriculture
cg.contributor.affiliationInternational Livestock Research Institute
cg.coverage.regionAfrica
cg.coverage.regionCentral Africa
cg.coverage.countryDemocratic Republic of the Congo
cg.coverage.hubCentral Africa Hub
cg.isijournalISI Journal
cg.authorship.typesCGIAR and developing country institute
cg.iitasubjectAgronomy
cg.iitasubjectFood Security
cg.iitasubjectGenetic Improvement
cg.iitasubjectPlant Breeding
cg.iitasubjectPlant Genetic Resources
cg.iitasubjectPlant Production
cg.journalGenes
cg.notesOpen Access Journal
cg.accessibilitystatusOpen Access
cg.reviewstatusPeer Review
cg.usagerightslicenseCreative Commons Attribution 4.0 (CC BY 0.0)
cg.targetaudienceScientists
cg.identifier.doihttps://doi.org/10.3390/genes14091815
cg.iitaauthor.identifierPaul Kitenge Kimwemwe: 0000-0002-1006-8207
cg.iitaauthor.identifierDONTSOP NGUEZET Paul Martin: 0000-0001-5098-1853
cg.futureupdate.requiredNo
cg.identifier.issue9: 1915
cg.identifier.volume14


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