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Segmental duplications drive the evolution of accessory regions in a major crop pathogen

dc.contributor.authorvan Westerhoven, A.C.
dc.contributor.authorAguilera-Galvez, C.
dc.contributor.authorNakasato-Tagami, G.
dc.contributor.authorShi-Kunne, X.
dc.contributor.authorde la Parte, E.M.
dc.contributor.authorChavarro-Carrero, E.
dc.contributor.authorMeijer, H.J.G.
dc.contributor.authorFeurtey, A.
dc.contributor.authorMaryani, N.
dc.contributor.authorOrdonez, N.
dc.contributor.authorSchneiders, H.
dc.contributor.authorNijbroek, K.
dc.contributor.authorWittenberg, A.H.J.
dc.contributor.authorHofstede, R.
dc.contributor.authorGarcía-Bastidas, F.
dc.contributor.authorSorensen, A.
dc.contributor.authorSwennen, R.
dc.contributor.authorDrenth, A.
dc.contributor.authorStukenbrock, E.H.
dc.contributor.authorKema, G.H.J.
dc.contributor.authorSeidl, M.F.
dc.date.accessioned2024-10-04T09:32:25Z
dc.date.available2024-10-04T09:32:25Z
dc.date.issued2024-04
dc.identifier.citationvan Westerhoven, A. C., Aguilera‐Galvez, C., Nakasato‐Tagami, G., Shi‐Kunne, X., Martinez de la Parte, E., Chavarro‐Carrero, E., ... & Seidl, M. F. (2024). Segmental duplications drive the evolution of accessory regions in a major crop pathogen. New Phytologist, 242(2), 610-625.
dc.identifier.issn0028-646X
dc.identifier.urihttps://hdl.handle.net/20.500.12478/8577
dc.description.abstractMany pathogens evolved compartmentalized genomes with conserved core and variable accessory regions (ARs) that carry effector genes mediating virulence. The fungal plant pathogen Fusarium oxysporum has such ARs, often spanning entire chromosomes. The presence of specific ARs influences the host range, and horizontal transfer of ARs can modify the pathogenicity of the receiving strain. However, how these ARs evolve in strains that infect the same host remains largely unknown. We defined the pan-genome of 69 diverse F. oxysporum strains that cause Fusarium wilt of banana, a significant constraint to global banana production, and analyzed the diversity and evolution of the ARs. Accessory regions in F. oxysporum strains infecting the same banana cultivar are highly diverse, and we could not identify any shared genomic regions and in planta-induced effectors. We demonstrate that segmental duplications drive the evolution of ARs. Furthermore, we show that recent segmental duplications specifically in accessory chromosomes cause the expansion of ARs in F. oxysporum. Taken together, we conclude that extensive recent duplications drive the evolution of ARs in F. oxysporum, which contribute to the evolution of virulence.
dc.description.sponsorshipBill & Melinda Gates Foundation
dc.description.sponsorshipDutch Dioraphte Foundation
dc.format.extent610-625
dc.language.isoen
dc.subjectFusarium Oxysporum
dc.subjectGenomes
dc.subjectPathogens
dc.subjectEvolution
dc.titleSegmental duplications drive the evolution of accessory regions in a major crop pathogen
dc.typeJournal Article
cg.contributor.crpRoots, Tubers and Bananas
cg.contributor.affiliationWageningen University & Research
cg.contributor.affiliationChristian-Albrechts University of Kiel
cg.contributor.affiliationUniversitas Sultan Ageng Tirtayasa
cg.contributor.affiliationKeyGene, Wageningen, the Netherlands
cg.contributor.affiliationInternational Institute of Tropical Agriculture
cg.contributor.affiliationUniversity of Queensland
cg.coverage.regionACP
cg.coverage.regionEurope
cg.coverage.regionNorth America
cg.coverage.countryThe Netherlands
cg.coverage.countryUnited States of America
cg.coverage.hubEastern Africa Hub
cg.researchthemeBiotech and Plant Breeding
cg.identifier.bibtexciteidVAN WESTERHOVEN:2024
cg.isijournalISI Journal
cg.authorship.typesCGIAR and advanced research institute
cg.iitasubjectFood Security
cg.iitasubjectGenetic Improvement
cg.iitasubjectPlant Health
cg.iitasubjectPlant Production
cg.journalNew Phytologist
cg.notesOpen Access Article
cg.accessibilitystatusOpen Access
cg.reviewstatusPeer Review
cg.usagerightslicenseCreative Commons Attribution 4.0 (CC BY 0.0)
cg.targetaudienceScientists
cg.identifier.doihttps://doi.org/10.1111/nph.19604
cg.iitaauthor.identifierRony Swennen: 0000-0002-5258-9043
cg.futureupdate.requiredNo
cg.identifier.issue2
cg.identifier.volume242


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