Show simple item record

dc.contributor.authorWolfe, M.D.
dc.contributor.authorRabbi, Ismail Y
dc.contributor.authorEgesi, Chiedozie N.
dc.contributor.authorHamblin, M.
dc.contributor.authorKawuki, R.
dc.contributor.authorKulakow, P.A.
dc.contributor.authorLozano, R.
dc.contributor.authorCarpio, D.P. del
dc.contributor.authorRamu, P.
dc.contributor.authorJannink, Jean-Luc
dc.date.accessioned2019-12-04T10:58:22Z
dc.date.available2019-12-04T10:58:22Z
dc.date.issued2016-07-15
dc.identifier.citationWolfe, M. D., Rabbi, I. Y., Egesi, C., Hamblin, M., Kawuki, R., Kulakow, P., ... & Jannink, J. L. (2016). Genome-Wide Association and Prediction Reveals Genetic Architecture of Cassava Mosaic Disease Resistance and Prospects for Rapid Genetic Improvement. The Plant Genome, 9(2), 1-13.
dc.identifier.issn1940-3372
dc.identifier.urihttps://hdl.handle.net/20.500.12478/974
dc.descriptionPublished: 13 May 2016
dc.description.abstractCassava (Manihot esculenta Crantz) is a crucial, under-researched crop feeding millions worldwide, especially in Africa. Cassava mosaic disease (CMD) has plagued production in Africa for over a century. Biparental mapping studies suggest primarily a single major gene mediates resistance. To investigate this genetic architecture, we conducted the first genome-wide association mapping study in cassava with up to 6128 genotyping-by-sequenced African breeding lines and 42,113 reference genome-mapped single-nucleotide polymorphism (SNP) markers. We found a single region on chromosome 8 that accounts for 30 to 66% of genetic resistance in the African cassava germplasm. Thirteen additional regions with small effects were also identified. Further dissection of the major quantitative trait locus (QTL) on chromosome 8 revealed the presence of two possibly epistatic loci and/or multiple resistance alleles, which may account for the difference between moderate and strong disease resistances in the germplasm. Search of potential candidate genes in the major QTL region identified two peroxidases and one thioredoxin. Finally, we found genomic prediction accuracy of 0.53 to 0.58 suggesting that genomic selection (GS) will be effective both for improving resistance in breeding populations and identifying highly resistant clones as varieties.
dc.format.extent1-13
dc.language.isoen
dc.subjectGenetic Gain
dc.subjectGermplasm Collections
dc.titleGenome-wide association and prediction reveals genetic architecture of cassava mosaic disease resistance and prospects for rapid genetic improvement
dc.typeJournal Article
dc.description.versionPeer Review
cg.contributor.crpRoots, Tubers and Bananas
cg.contributor.affiliationCornell University
cg.contributor.affiliationInternational Institute of Tropical Agriculture
cg.contributor.affiliationNational Root Crops Research Institute, Nigeria
cg.contributor.affiliationNational Crops Resources Research Institute, Uganda
cg.contributor.affiliationUnited States Department of Agriculture
cg.coverage.regionAfrica
cg.coverage.regionWest Africa
cg.coverage.countryNigeria
cg.isijournalISI Journal
cg.authorship.typesCGIAR and developing country institute
cg.authorship.typesCGIAR and advanced research institute
cg.iitasubjectCassava
cg.journalThe Plant Genome
cg.howpublishedFormally Published
cg.accessibilitystatusOpen Access
local.dspaceid77751
cg.targetaudienceScientists
cg.identifier.doihttps://dx.doi.org/10.3835/plantgenome2015.11.0118


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record