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    Historical environmental change in Africa drives divergence and admixture of Aedes aegypti mosquitoes: a precursor to successful worldwide colonization?

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    U16ArtBennettHistoricalInthomDev.pdf (687.9Kb)
    Date
    2016-08-10
    Author
    Bennett, K.L.
    Shija, F.
    Linton, Y.
    Misinzo, G.
    Kaddumukasa, M.
    Djouaka, R.F.
    Anyaele, O.
    Harris, Angela
    Irish, S.
    Hlaing, T.
    Prakash, A.
    Lutwama, J.
    Walton, C.
    Type
    Journal Article
    Target Audience
    Scientists
    Metadata
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    Abstract/Description
    Increasing globalization has promoted the spread of exotic species, including disease vectors. Understanding the evolutionary processes involved in such colonizations is both of intrinsic biological interest and important to predict and mitigate future disease risks. The Aedes aegypti mosquito is a major vector of dengue, chikungunya and Zika, the worldwide spread of which has been facilitated by Ae. aegypti's adaption to human-modified environments. Understanding the evolutionary processes involved in this invasion requires characterization of the genetic make-up of the source population(s). The application of approximate Bayesian computation (ABC) to sequence data from four nuclear and one mitochondrial marker revealed that African populations of Ae. aegypti best fit a demographic model of lineage diversification, historical admixture and recent population structuring. As ancestral Ae. aegypti were dependent on forests, this population history is consistent with the effects of forest fragmentation and expansion driven by Pleistocene climatic change. Alternatively, or additionally, historical human movement across the continent may have facilitated their recent spread and mixing. ABC analysis and haplotype networks support earlier inferences of a single out-of-Africa colonization event, while a cline of decreasing genetic diversity indicates that Ae. aegypti moved first from Africa to the Americas and then to Asia. ABC analysis was unable to verify this colonization route, possibly because the genetic signal of admixture obscures the true colonization pathway. By increasing genetic diversity and forming novel allelic combinations, divergence and historical admixture within Africa could have provided the adaptive potential needed for the successful worldwide spread of Ae. aegypti.
    https://dx.doi.org/10.1111/mec.13762
    Multi standard citation
    Permanent link to this item
    https://hdl.handle.net/20.500.12478/1319
    Digital Object Identifier (DOI)
    https://dx.doi.org/10.1111/mec.13762
    IITA Subjects
    Climate Change; Genetic Improvement
    Agrovoc Terms
    Arbovirus; Domestication; Forest Fragmentation; Invasive Species; Climate Change; Aedes Aegypti; Mosquitoes; Genotypes; Dna
    Regions
    Central Africa; East Africa; West Africa
    Journals
    Molecular Ecology
    Collections
    • Journal and Journal Articles4835
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