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Historical environmental change in Africa drives divergence and admixture of Aedes aegypti mosquitoes: a precursor to successful worldwide colonization?

dc.contributor.authorBennett, K.L.
dc.contributor.authorShija, F.
dc.contributor.authorLinton, Y.
dc.contributor.authorMisinzo, G.
dc.contributor.authorKaddumukasa, M.
dc.contributor.authorDjouaka, R.F.
dc.contributor.authorAnyaele, O.
dc.contributor.authorHarris, Angela
dc.contributor.authorIrish, S.
dc.contributor.authorHlaing, T.
dc.contributor.authorPrakash, A.
dc.contributor.authorLutwama, J.
dc.contributor.authorWalton, C.
dc.date.accessioned2019-12-04T11:04:02Z
dc.date.available2019-12-04T11:04:02Z
dc.date.issued2016-08-10
dc.identifier.citationBennett, K.L., Shija, F., Linton, Y., Misinzo, G., Kaddumukasa, M., Djouaka, R.F., ... & Anyaele, O. (2016). Historical environmental change in Africa drives divergence and admixture of Aedes aegypti mosquitoes: a precursor to successful worldwide colonization? Molecular Ecology, 1-11.
dc.identifier.issn0962-1083
dc.identifier.urihttps://hdl.handle.net/20.500.12478/1319
dc.descriptionArticle Purchased
dc.description.abstractIncreasing globalization has promoted the spread of exotic species, including disease vectors. Understanding the evolutionary processes involved in such colonizations is both of intrinsic biological interest and important to predict and mitigate future disease risks. The Aedes aegypti mosquito is a major vector of dengue, chikungunya and Zika, the worldwide spread of which has been facilitated by Ae. aegypti's adaption to human-modified environments. Understanding the evolutionary processes involved in this invasion requires characterization of the genetic make-up of the source population(s). The application of approximate Bayesian computation (ABC) to sequence data from four nuclear and one mitochondrial marker revealed that African populations of Ae. aegypti best fit a demographic model of lineage diversification, historical admixture and recent population structuring. As ancestral Ae. aegypti were dependent on forests, this population history is consistent with the effects of forest fragmentation and expansion driven by Pleistocene climatic change. Alternatively, or additionally, historical human movement across the continent may have facilitated their recent spread and mixing. ABC analysis and haplotype networks support earlier inferences of a single out-of-Africa colonization event, while a cline of decreasing genetic diversity indicates that Ae. aegypti moved first from Africa to the Americas and then to Asia. ABC analysis was unable to verify this colonization route, possibly because the genetic signal of admixture obscures the true colonization pathway. By increasing genetic diversity and forming novel allelic combinations, divergence and historical admixture within Africa could have provided the adaptive potential needed for the successful worldwide spread of Ae. aegypti.
dc.description.sponsorshipNatural Environment Research Council, United Kingdom
dc.description.sponsorshipLeverhulme Trust
dc.format.extent1-18
dc.language.isoen
dc.subjectArbovirus
dc.subjectDomestication
dc.subjectForest Fragmentation
dc.subjectInvasive Species
dc.subjectClimate Change
dc.subjectAedes Aegypti
dc.subjectMosquitoes
dc.subjectGenotypes
dc.subjectDna
dc.titleHistorical environmental change in Africa drives divergence and admixture of Aedes aegypti mosquitoes: a precursor to successful worldwide colonization?
dc.typeJournal Article
dc.description.versionPeer Review
cg.contributor.crpGenebanks
cg.contributor.crpClimate Change, Agriculture and Food Security
cg.contributor.affiliationUniversity of Manchester
cg.contributor.affiliationSmithsonian Institution Museum Support Center
cg.contributor.affiliationSokoine University of Agriculture
cg.contributor.affiliationUganda Virus Research Institute
cg.contributor.affiliationInternational Institute of Tropical Agriculture
cg.contributor.affiliationUniversity of Ibadan
cg.contributor.affiliationCayman Islands Government
cg.contributor.affiliationLondon School of Hygiene and Tropical Medicine
cg.contributor.affiliationMinistry of Health, Myanmar
cg.contributor.affiliationNational Institute for Research in Environmental Health, India
cg.coverage.regionCentral Africa
cg.coverage.regionEast Africa
cg.coverage.regionWest Africa
cg.isijournalISI Journal
cg.authorship.typesCGIAR and developing country institute
cg.iitasubjectClimate Change
cg.iitasubjectGenetic Improvement
cg.journalMolecular Ecology
cg.howpublishedFormally Published
cg.accessibilitystatusOpen Access
local.dspaceid79048
cg.targetaudienceScientists
cg.identifier.doihttps://dx.doi.org/10.1111/mec.13762


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