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    Highthroughput genomic sequencing of cassava bacterial blight strains identifies conserved effectors to target for durable resistance

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    Date
    2012-07
    Author
    Bart, R.
    Cohn, M.
    Kassen, A.
    McCallum, E.
    Shybut, M.
    Petriello, A.
    Krasileva, K.
    Dahlbeck, D.
    Medina, C.
    Alicai, Titus
    Kumar, P.L.
    Moreira, L.
    Neto, J.
    Verdier, Valérie
    Santana, M.
    Kositcharoenkul, N.
    Vanderschuren, H.
    Gruissem, W.
    Bernal, A.
    Staskawicz, B.
    Type
    Journal Article
    Metadata
    Show full item record
    Abstract/Description
    Cassava bacterial blight (CBB), incited by Xanthomonas axonopodis pv. manihotis (Xam), is the most important bacterial disease of cassava, a staple food source for millions of people in developing countries. Here we present a widely applicable strategy for elucidating the virulence components of a pathogen population. We report Illumina-based draft genomes for 65 Xam strains and deduce the phylogenetic relatedness of Xam across the areas where cassava is grown. Using an extensive database of effector proteins from animal and plant pathogens, we identify the effector repertoire for each sequenced strain and use a comparative sequence analysis to deduce the least polymorphic of the conserved effectors. These highly conserved effectors have been maintained over 11 countries, three continents, and 70 y of evolution and as such represent ideal targets for developing resistance strategies.
    https://dx.doi.org/10.1073/pnas.1208003109
    Multi standard citation
    Permanent link to this item
    https://hdl.handle.net/20.500.12478/1570
    Digital Object Identifier (DOI)
    https://dx.doi.org/10.1073/pnas.1208003109
    IITA Subjects
    Cassava; Plant Diseases; Disease Control; Plant Genetic Resources
    Agrovoc Terms
    Innate Immunity; Type Three Effectors; Next-Generation Sequencing; Cassava; Plant Diseases; Xanthomonas Axonopodis Pv. Manihotis
    Regions
    Africa; East Africa; West Africa
    Countries
    Uganda; Nigeria
    Journals
    Proceedings of the National Academy of Sciences
    Collections
    • Journal and Journal Articles4835
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