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dc.contributor.authorBart, R.
dc.contributor.authorCohn, M.
dc.contributor.authorKassen, A.
dc.contributor.authorMcCallum, E.
dc.contributor.authorShybut, M.
dc.contributor.authorPetriello, A.
dc.contributor.authorKrasileva, K.
dc.contributor.authorDahlbeck, D.
dc.contributor.authorMedina, C.
dc.contributor.authorAlicai, Titus
dc.contributor.authorKumar, P.L.
dc.contributor.authorMoreira, L.
dc.contributor.authorNeto, J.
dc.contributor.authorVerdier, Valérie
dc.contributor.authorSantana, M.
dc.contributor.authorKositcharoenkul, N.
dc.contributor.authorVanderschuren, H.
dc.contributor.authorGruissem, W.
dc.contributor.authorBernal, A.
dc.contributor.authorStaskawicz, B.
dc.identifier.citationBart, R., Cohn, M., Kassen, A., McCallum, E., Shybut, M., Petriello, A., … Staskawicz, B. (2012). Highthroughput genomic sequencing of cassava bacterial blight strains identifies conserved effectors to target for durable. Resistance. In: Proceedings of the National Academy of Sciences of the United States of America, 109(28), E1972-E1979.
dc.descriptionPublished online: 13 June 2012
dc.description.abstractCassava bacterial blight (CBB), incited by Xanthomonas axonopodis pv. manihotis (Xam), is the most important bacterial disease of cassava, a staple food source for millions of people in developing countries. Here we present a widely applicable strategy for elucidating the virulence components of a pathogen population. We report Illumina-based draft genomes for 65 Xam strains and deduce the phylogenetic relatedness of Xam across the areas where cassava is grown. Using an extensive database of effector proteins from animal and plant pathogens, we identify the effector repertoire for each sequenced strain and use a comparative sequence analysis to deduce the least polymorphic of the conserved effectors. These highly conserved effectors have been maintained over 11 countries, three continents, and 70 y of evolution and as such represent ideal targets for developing resistance strategies.
dc.description.sponsorshipNational Science Foundation
dc.subjectInnate Immunity
dc.subjectType Three Effectors
dc.subjectNext-Generation Sequencing
dc.subjectPlant Diseases
dc.subjectXanthomonas Axonopodis Pv. Manihotis
dc.titleHighthroughput genomic sequencing of cassava bacterial blight strains identifies conserved effectors to target for durable resistance
dc.typeJournal Article
dc.description.versionPeer Review
cg.contributor.crpRoots, Tubers and Bananas
cg.contributor.affiliationUniversity of California
cg.contributor.affiliationEidgenössische Technische Hochschule Zürich
cg.contributor.affiliationUniversidad de los Andes
cg.contributor.affiliationNational Crops Resources Research Institute, Uganda
cg.contributor.affiliationInternational Institute of Tropical Agriculture
cg.contributor.affiliationUniversidade Federal de Ouro Preto
cg.contributor.affiliationUniversité de Montpellier
cg.contributor.affiliationUniversidad Simón Bolívar
cg.contributor.affiliationPlant Protection Research and Development Office, Thailand
cg.coverage.regionEast Africa
cg.coverage.regionWest Africa
cg.authorship.typesCGIAR and developing country institute
cg.iitasubjectPlant Diseases
cg.iitasubjectDisease Control
cg.iitasubjectPlant Genetic Resources
cg.journalProceedings of the National Academy of Sciences
cg.howpublishedFormally Published
cg.accessibilitystatusLimited Access

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