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    Cassava haplotype map highlights fixation of deleterious mutations during clonal propagation

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    U17ArtRamuCassavaInthomDev.pdf (726.9Kb)
    Date
    2017-04-17
    Author
    Ramu, P.
    Esuma, W.
    Kawuki, R.
    Rabbi, Ismail Y
    Egesi, Chiedozie N.
    Bredeson, J.V.
    Bart, R.S.
    Verma, J.
    Buckler, E.S.
    Lu, F
    Type
    Journal Article
    Target Audience
    Scientists
    Metadata
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    Abstract/Description
    Cassava (Manihot esculenta Crantz) is an important staple food crop in Africa and South America; however, ubiquitous deleterious mutations may severely decrease its fitness. To evaluate these deleterious mutations, we constructed a cassava haplotype map through deep sequencing 241 diverse accessions and identified >28 million segregating variants. We found that (i) although domestication has modified starch and ketone metabolism pathways to allow for human consumption, the concomitant bottleneck and clonal propagation have resulted in a large proportion of fixed deleterious amino acid changes, increased the number of deleterious alleles by 26%, and shifted the mutational burden toward common variants; (ii) deleterious mutations have been ineffectively purged, owing to limited recombination in the cassava genome; (iii) recent breeding efforts have maintained yield by masking the most damaging recessive mutations in the heterozygous state but have been unable to purge the mutation burden; such purging should be a key target in future cassava breeding.
    http://dx.doi.org/10.1038/ng.3845
    Multi standard citation
    Permanent link to this item
    https://hdl.handle.net/20.500.12478/1767
    Digital Object Identifier (DOI)
    http://dx.doi.org/10.1038/ng.3845
    Research Themes
    BIOTECH & PLANT BREEDING
    IITA Subjects
    Cassava; Plant Breeding
    Agrovoc Terms
    Genomics; Plant Genetics; Population Genetics; Cassava; Deleterious Mutations; Haplotype Map; Clonal Propagation
    Journals
    Nature Genetics
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    • Journal and Journal Articles5283
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