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    Acetylcholinesterase (ace‑1R) target site mutation G119S and resistance to carbamates in Anopheles gambiae (sensu lato) populations from Mali

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    Journal Article (1.571Mb)
    Date
    2020
    Author
    Keïta, M.
    Kané, F.
    Thiero, O.
    Traoré, B.
    Zeukeng, F.
    Sodio, A.B.
    Traore, S.F.
    Djouaka, R.F.
    Doumbia, S.
    Sogoba, N.
    Type
    Journal Article
    Review Status
    Peer Review
    Target Audience
    Scientists
    Metadata
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    Abstract/Description
    Background The long-lasting insecticidal nets (LLINs) and indoor residual spraying of insecticide (IRS) are major malaria vector control strategies in Mali. The success of control strategies depends on a better understanding of the status of malaria vectors with respect to the insecticides used. In this study we evaluate the level of resistance of Anopheles gambiae (sensu lato) to bendiocarb and the molecular mechanism that underlies it. Methods Larvae of An. gambiae (s.l.) were collected from breeding habitats encountered in the three study sites and bioassayed with bendiocarb. The ace-1 target site substitution G119S was genotyped using a TaqMan assay. Results The three species of the An. gambiae complex in Mali, i.e. An. arabiensis, An. coluzzii and An. gambiae (s.s.) were found in sympatry in the three surveyed localities with different frequencies. We observed a resistance and suspicious resistance of the three species to bendiocarb with a mortality rate ranging from 37% to 86%. The allelic frequency of the G119S mutation was higher in An. gambiae (s.s.) compared to the other two species; 42.86%, 25.61% and 16.67% respectively in Dangassa, Koula, and Karadié. The allelic frequency of G119S in An. coluzzii ranged from 4.5% to 8.33% and from 1.43% to 21.15% for An. arabiensis. After exposure to bendiocarb, the G119S mutation was found only in survivors. The survival of Anopheles gambiae (s.l) populations from the three surveyed localities was associated with the presence of the mutation. Conclusions The study highlights the implication of G119S mutation in bendiocarb resistance in An. gambiae (s.s.), An. arabiensis and An. coluzzii populations from the three surveyed localities.
    https://dx.doi.org/10.1186/s13071-020-04150-x
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    Permanent link to this item
    https://hdl.handle.net/20.500.12478/7663
    IITA Authors ORCID
    Rousseau Djouakahttps://orcid.org/0000-0003-4772-0753
    Digital Object Identifier (DOI)
    https://dx.doi.org/10.1186/s13071-020-04150-x
    Research Themes
    Nutrition and Human Health
    IITA Subjects
    Disease Control
    Agrovoc Terms
    Malaria; Mali; Anopheles Gambiae; Vectors; Defence Mechanisms
    Regions
    Africa; West Africa
    Countries
    Mali
    Hubs
    Headquarters and Western Africa Hub
    Journals
    Parasites & Vectors
    Collections
    • Journal and Journal Articles4835
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