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dc.contributor.authorKeïta, M.
dc.contributor.authorKané, F.
dc.contributor.authorThiero, O.
dc.contributor.authorTraoré, B.
dc.contributor.authorZeukeng, F.
dc.contributor.authorSodio, A.B.
dc.contributor.authorTraore, S.F.
dc.contributor.authorDjouaka, R.F.
dc.contributor.authorDoumbia, S.
dc.contributor.authorSogoba, N.
dc.date.accessioned2022-08-19T08:43:49Z
dc.date.available2022-08-19T08:43:49Z
dc.date.issued2020
dc.identifier.citationKeïta, M., Kané, F., Thiero, O., Traoré, B., Zeukeng, F., Sodio, A.B., ... & Sogoba, N. (2020). Acetylcholinesterase (ace-1 R) target site mutation G119S and resistance to carbamates in Anopheles gambiae (sensu lato) populations from Mali. Parasites & Vectors, 13(283), 1-9.
dc.identifier.issn1756-3305
dc.identifier.urihttps://hdl.handle.net/20.500.12478/7663
dc.description.abstractBackground The long-lasting insecticidal nets (LLINs) and indoor residual spraying of insecticide (IRS) are major malaria vector control strategies in Mali. The success of control strategies depends on a better understanding of the status of malaria vectors with respect to the insecticides used. In this study we evaluate the level of resistance of Anopheles gambiae (sensu lato) to bendiocarb and the molecular mechanism that underlies it. Methods Larvae of An. gambiae (s.l.) were collected from breeding habitats encountered in the three study sites and bioassayed with bendiocarb. The ace-1 target site substitution G119S was genotyped using a TaqMan assay. Results The three species of the An. gambiae complex in Mali, i.e. An. arabiensis, An. coluzzii and An. gambiae (s.s.) were found in sympatry in the three surveyed localities with different frequencies. We observed a resistance and suspicious resistance of the three species to bendiocarb with a mortality rate ranging from 37% to 86%. The allelic frequency of the G119S mutation was higher in An. gambiae (s.s.) compared to the other two species; 42.86%, 25.61% and 16.67% respectively in Dangassa, Koula, and Karadié. The allelic frequency of G119S in An. coluzzii ranged from 4.5% to 8.33% and from 1.43% to 21.15% for An. arabiensis. After exposure to bendiocarb, the G119S mutation was found only in survivors. The survival of Anopheles gambiae (s.l) populations from the three surveyed localities was associated with the presence of the mutation. Conclusions The study highlights the implication of G119S mutation in bendiocarb resistance in An. gambiae (s.s.), An. arabiensis and An. coluzzii populations from the three surveyed localities.
dc.description.sponsorshipTDR/WHO
dc.format.extent1-9
dc.language.isoen
dc.subjectMalaria
dc.subjectMali
dc.subjectAnopheles Gambiae
dc.subjectVectors
dc.subjectDefence Mechanisms
dc.titleAcetylcholinesterase (ace‑1R) target site mutation G119S and resistance to carbamates in Anopheles gambiae (sensu lato) populations from Mali
dc.typeJournal Article
cg.contributor.crpAgriculture for Nutrition and Health
cg.contributor.affiliationUniversity of Sciences, Techniques and Technologies of Bamako
cg.contributor.affiliationInternational Institute of Tropical Agriculture
cg.coverage.regionAfrica
cg.coverage.regionWest Africa
cg.coverage.countryMali
cg.coverage.hubHeadquarters and Western Africa Hub
cg.researchthemeNutrition and Human Health
cg.identifier.bibtexciteidKEITA:2020
cg.isijournalISI Journal
cg.authorship.typesCGIAR and developing country institute
cg.iitasubjectDisease Control
cg.journalParasites & Vectors
cg.notesPublished online: 05 Jun 2020
cg.accessibilitystatusOpen Access
cg.reviewstatusPeer Review
cg.usagerightslicenseCreative Commons Attribution 4.0 (CC BY 0.0)
cg.targetaudienceScientists
cg.identifier.doihttps://dx.doi.org/10.1186/s13071-020-04150-x
cg.iitaauthor.identifierRousseau Djouaka: 0000-0003-4772-0753
cg.futureupdate.requiredNo
cg.identifier.issue283
cg.identifier.volume13


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