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    Hybrids of RNA viruses and viroid-like elements replicate in fungi

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    Journal Article (2.563Mb)
    Date
    2023-05-05
    Author
    Forgia, M.
    Navarro, B.
    Daghino, S.
    Cervera, A.
    Gisel, A.
    Perotto, S.
    Aghayeva, D.N.
    Akinyuwa, M.F.
    Gobbi, E.
    Zheludev, I.N.
    Edgar, R.C.
    Chikhi, R.
    Turina, M.
    Babaian, A.
    Di Serio, F.
    de la Peña, M.
    Type
    Journal Article
    Review Status
    Peer Review
    Target Audience
    Scientists
    Metadata
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    Abstract/Description
    Earth’s lifemay have originated as self-replicating RNA, and it has been argued that RNA viruses and viroid-like elements are remnants of such pre-cellular RNA world. RNA viruses are defined by linear RNA genomes encoding an RNAdependent RNA polymerase (RdRp), whereas viroid-like elements consist of small, single-stranded, circular RNA genomes that, in some cases, encode paired self-cleaving ribozymes. Here we show that the number of candidate viroid-like elements occurring in geographically and ecologically diverse niches is much higher than previously thought. We report that, amongst these circular genomes, fungal ambiviruses are viroid-like elements that undergo rolling circle replication and encode their own viral RdRp. Thus, ambiviruses are distinct infectious RNAs showing hybrid features of viroid-like RNAs and viruses. We also detected similar circular RNAs, containing active ribozymes and encoding RdRps, related to mitochondrial-like fungal viruses, highlighting fungi as an evolutionary hub for RNA viruses and viroid-like elements. Our findings point to a deep co-evolutionary history between RNA viruses and subviral elements and offer new perspectives in the origin and evolution of primordial infectious agents, and RNA life.
    https://doi.org/10.1038/s41467-023-38301-2
    Multi standard citation
    Permanent link to this item
    https://hdl.handle.net/20.500.12478/8176
    IITA Authors ORCID
    ANDREAS GISELhttps://orcid.org/0000-0001-7218-9488
    Digital Object Identifier (DOI)
    https://doi.org/10.1038/s41467-023-38301-2
    Research Themes
    Biotech and Plant Breeding
    IITA Subjects
    Disease Control; Genetic Improvement
    Agrovoc Terms
    Rna; Viruses; Genomes; Fungi
    Regions
    Europe
    Countries
    Italy
    Hubs
    Headquarters and Western Africa Hub
    Journals
    Nature Communications
    Collections
    • Journal and Journal Articles4943
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