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Hybrids of RNA viruses and viroid-like elements replicate in fungi

dc.contributor.authorForgia, M.
dc.contributor.authorNavarro, B.
dc.contributor.authorDaghino, S.
dc.contributor.authorCervera, A.
dc.contributor.authorGisel, A.
dc.contributor.authorPerotto, S.
dc.contributor.authorAghayeva, D.N.
dc.contributor.authorAkinyuwa, M.F.
dc.contributor.authorGobbi, E.
dc.contributor.authorZheludev, I.N.
dc.contributor.authorEdgar, R.C.
dc.contributor.authorChikhi, R.
dc.contributor.authorTurina, M.
dc.contributor.authorBabaian, A.
dc.contributor.authorDi Serio, F.
dc.contributor.authorde la Peña, M.
dc.date.accessioned2023-05-23T07:47:55Z
dc.date.available2023-05-23T07:47:55Z
dc.date.issued2023-05-05
dc.identifier.citationForgia, M., Navarro, B., Daghino, S., Cervera, A., Gisel, A., Perotto, S., ... & de la Peña, M. (2023). Hybrids of RNA viruses and viroid-like elements replicate in fungi. Nature Communications, 14: 2591, 1-11.
dc.identifier.issn2041-1723
dc.identifier.urihttps://hdl.handle.net/20.500.12478/8176
dc.description.abstractEarth’s lifemay have originated as self-replicating RNA, and it has been argued that RNA viruses and viroid-like elements are remnants of such pre-cellular RNA world. RNA viruses are defined by linear RNA genomes encoding an RNAdependent RNA polymerase (RdRp), whereas viroid-like elements consist of small, single-stranded, circular RNA genomes that, in some cases, encode paired self-cleaving ribozymes. Here we show that the number of candidate viroid-like elements occurring in geographically and ecologically diverse niches is much higher than previously thought. We report that, amongst these circular genomes, fungal ambiviruses are viroid-like elements that undergo rolling circle replication and encode their own viral RdRp. Thus, ambiviruses are distinct infectious RNAs showing hybrid features of viroid-like RNAs and viruses. We also detected similar circular RNAs, containing active ribozymes and encoding RdRps, related to mitochondrial-like fungal viruses, highlighting fungi as an evolutionary hub for RNA viruses and viroid-like elements. Our findings point to a deep co-evolutionary history between RNA viruses and subviral elements and offer new perspectives in the origin and evolution of primordial infectious agents, and RNA life.
dc.format.extent1-11
dc.language.isoen
dc.subjectRna
dc.subjectViruses
dc.subjectGenomes
dc.subjectFungi
dc.titleHybrids of RNA viruses and viroid-like elements replicate in fungi
dc.typeJournal Article
cg.contributor.crpRoots, Tubers and Bananas
cg.contributor.affiliationNational Research Council of Italy
cg.contributor.affiliationUniversidad Politécnica de Valencia
cg.contributor.affiliationInternational Institute of Tropical Agriculture
cg.contributor.affiliationUniversity of Torino
cg.contributor.affiliationMinistry of Science and Education of the Republic of Azerbaijan
cg.contributor.affiliationUniversità Degli Studi di Padova
cg.contributor.affiliationUniversity of Brescia
cg.contributor.affiliationStanford University
cg.contributor.affiliationIndependent Researcher, USA
cg.contributor.affiliationInstitut Pasteur, France
cg.contributor.affiliationUniversity of Toronto
cg.contributor.affiliationAuburn University
cg.coverage.regionEurope
cg.coverage.countryItaly
cg.coverage.hubHeadquarters and Western Africa Hub
cg.researchthemeBiotech and Plant Breeding
cg.isijournalISI Journal
cg.authorship.typesCGIAR and advanced research institute
cg.iitasubjectDisease Control
cg.iitasubjectGenetic Improvement
cg.journalNature Communications
cg.notesOpen Access Journal; Published online: 05 May 2023
cg.accessibilitystatusOpen Access
cg.reviewstatusPeer Review
cg.usagerightslicenseCreative Commons Attribution 4.0 (CC BY 0.0)
cg.targetaudienceScientists
cg.identifier.doihttps://doi.org/10.1038/s41467-023-38301-2
cg.iitaauthor.identifierANDREAS GISEL: 0000-0001-7218-9488
cg.futureupdate.requiredNo
cg.identifier.issue1: 2591
cg.identifier.volume14


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