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Hydroxamic acids: New players in the multifactorial mechanisms of maize resistance to Striga hermonthica

dc.contributor.authorMarcotrigiano, R.A.
dc.contributor.authorCarluccio, A.V.
dc.contributor.authorUnachukwu, N.
dc.contributor.authorAdeoti, S.R.
dc.contributor.authorAbdulsalam, T.
dc.contributor.authorGedil, M.
dc.contributor.authorMenkir, A.
dc.contributor.authorGisel, A.
dc.contributor.authorStavolone, L.
dc.date.accessioned2024-01-09T09:44:45Z
dc.date.available2024-01-09T09:44:45Z
dc.date.issued2023-11
dc.identifier.citationMarcotrigiano, A.R., Carluccio, A.V., Unachukwu, N., Adeoti, S.R., Abdulsalam, T., Gedil, M., ... & Stavolone, L. (2023). Hydroxamic acids: New players in the multifactorial mechanisms of maize resistance to Striga hermonthica. Plant Physiology and Biochemistry, 204:108134, 1-10.
dc.identifier.issn0981-9428
dc.identifier.urihttps://hdl.handle.net/20.500.12478/8369
dc.description.abstractStriga hermonthica is the most widespread and destructive plant parasite infesting maize and other major crops in sub-Saharan Africa where it causes severe yield losses and threatens food security. Several tolerant maize lines supporting reduced S. hermonthica emergence have been deployed. However, the molecular bases of such resistance are yet poorly understood. Based on a time course comparative gene expression analysis between susceptible and resistant maize lines we have confirmed resistance mechanisms known to be activated upon plant parasite infestation and identified potential novel players worth further investigation e.g. iron homeostasis and mitochondrial respiration-related genes. Most intriguingly, we show a previously unknown strategy of maize post-attachment resistance based on DIMBOA accumulation in S. hermonthica-infested maize roots. S. hermonthica infestation triggers positive regulation of gene expression in the hydroxamic acid (HA) pathway culminating with an accumulation of benzoxazinoids (BX), known for their antifeedant, insecticidal, antimicrobial, and allelopathic activities. We demonstrate that HA root content is positively correlated with S. hermonthica resistance in the resistant parent and its progenies and in unrelated maize lines. Downregulation of HA genes causes increased susceptibility to S. hermonthica infestation in loss-of-function maize mutants. While the mechanism of BX action in parasitic plant resistance is yet to be uncovered, the potential of this discovery for developing effective control and breeding strategies is enormous.
dc.description.sponsorshipBill & Melinda Gates Foundation
dc.format.extent1-10
dc.language.isoen
dc.subjectHydroxamic Acids
dc.subjectStriga Hermonthica
dc.subjectMaize
dc.subjectSub-Saharan Africa
dc.titleHydroxamic acids: New players in the multifactorial mechanisms of maize resistance to Striga hermonthica
dc.typeJournal Article
cg.contributor.crpMaize
cg.contributor.affiliationInternational Institute of Tropical Agriculture
cg.coverage.regionAfrica
cg.coverage.regionWest Africa
cg.coverage.countryNigeria
cg.coverage.hubHeadquarters and Western Africa Hub
cg.researchthemeBiotech and Plant Breeding
cg.identifier.bibtexciteidMARCOTRIGIANO:2023
cg.isijournalISI Journal
cg.authorship.typesCGIAR Single Centre
cg.iitasubjectAgronomy
cg.iitasubjectFood Security
cg.iitasubjectMaize
cg.iitasubjectPlant Breeding
cg.iitasubjectPlant Production
cg.journalPlant Physiology and Biochemistry
cg.notesOpen Access Article
cg.accessibilitystatusOpen Access
cg.reviewstatusPeer Review
cg.usagerightslicenseCreative Commons Attribution 4.0 (CC BY 0.0)
cg.targetaudienceScientists
cg.identifier.doihttps://doi.org/10.1016/j.plaphy.2023.108134
cg.iitaauthor.identifierAnna Vittoria Carluccio: 0000-0001-6887-5792
cg.iitaauthor.identifierNnanna Unachukwu: 0000-0003-2701-2477
cg.iitaauthor.identifierMelaku Gedil: 0000-0002-6258-6014
cg.iitaauthor.identifierAbebe Menkir: 0000-0002-5907-9177
cg.iitaauthor.identifierANDREAS GISEL: 0000-0001-7218-9488
cg.iitaauthor.identifierLIVIA STAVOLONE: 0000-0002-0691-1302
cg.futureupdate.requiredNo
cg.identifier.issue108134
cg.identifier.volume204


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